Catalyzing progress.

Accelerating cures.

The Ladders to Cures (L2C) Scientific Accelerator at the Broad Institute of MIT and Harvard is an ambitious new initiative whose mission is to catalyze progress across the research ecosystem and accelerate advances leading to treatments and cures for patients with rare genetic diseases.

Rare genetic diseases are collectively common: they affect 1 in 10 people globally.

The growing list of rare genetic diseases currently stands at approximately 8,000, but fewer than 500 have an available treatment. The striking mismatch between these numbers underscores the urgent need to develop a new approach at scale to deliver precision cures at an accelerated pace.

WHO WE ARE

A community empowered for radical collaboration to solve biomedicine’s greatest challenges.

We are scientists, physicians, patient advocates, AI/machine learning experts, and biopharma veterans working together to gain new insights and advance treatments for rare genetic diseases.

Stylized digital sphere with radiating dots, illustrating nodal structures and interconnectedness in cellular biology or molecular research.

We are focused on vastly shortening the time to develop therapies for patients with chronic genetic diseases.

OUR RESEARCH

Our vision is to uncover as many biological and technological nodes as possible to accelerate treatments and cures for patients with rare genetic diseases.

Our Projects

  • 01 /

    Building flagship projects to harness biological and technological nodes across all rare genetic diseases.

  • 02 /

    Establishing close partnerships with patient-led advocacy groups.

  • 03 /

    Developing proof-of-concept therapeutic projects focusing on specific technological nodes or druggable targets.

  • 04 /

    Creating a rich community empowered for radical collaboration to solve biomedicine’s greatest challenges.